Thermo Fisher Scientific Human NPC1 Synthetic Peptide
인간 NPC1 단백질의 C-말단 15개 아미노산 서열 기반 합성 펩타이드. PA5-20753 항체의 차단 펩타이드로 사용 가능. 순도 높은 액상 형태로 제공되며 PBS(pH 7.2)와 0.1% BSA 포함. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human NPC1.
PEP-0867 can be used as a blocking peptide with polyclonal antibody PA5-20753.
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by abnormal sequestration of lipids including cholesterol and glycosphingolipids.
The NPC1 protein is a large protein located in the limiting membrane of endosomes and lysosomes, mediating intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol.
NPC1, along with FTO, MC4R, and PTER, has been identified as a risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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