Thermo Fisher Scientific Human LDLR Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human LDL-R.
PEP-0866 can be used as a blocking peptide with polyclonal antibody PA5-20752.

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Low density lipoprotein (LDL) is bound at the cell membrane and internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder.
LDL-R, along with SCARB1, CLDN1, and CD81, is also reported as an entry factor for the Hepatitis C virus.
At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.