Thermo Fisher Scientific Human LDLR Synthetic Peptide
인간 LDL 수용체 중심부 18개 아미노산 서열로 구성된 합성 펩타이드입니다. 항체 PA5-20752의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태이며 PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human LDL-R.
PEP-0866 can be used as a blocking peptide with polyclonal antibody PA5-20752.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Low density lipoprotein (LDL) is bound at the cell membrane and internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder.
LDL-R, along with SCARB1, CLDN1, and CD81, is also reported as an entry factor for the Hepatitis C virus.
At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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