Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI6B2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells.
Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex.
NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domains undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitors or Ca²⁺ chelators.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.