Thermo Fisher Scientific NLK Polyclonal Antibody
Rabbit polyclonal antibody specific to human NLK. Validated for WB and ICC/IF. Purified by antigen affinity chromatography. Supplied in PBS with glycerol and sodium azide. Suitable for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NLK. Recombinant protein control fragment (Product #RP-91434) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856245 |
Product Specific Information
Immunogen sequence:
LRGPHKQPSL PVLYTLSSQA THEAVHLLCR MLVFDPSKRI SAKDALAHPY LDEGRLRYHT CMCKCCFSTS TGRVYTSDFE PVTNPKFDDT FEKNLSSVRQ VKEIIHQFIL EQQKGNRVPL CINPQSAAFK SFISSTVAQP S
Target Information
NLK is a serine/threonine kinase involved in signal transduction and cellular communication. It acts as a positive effector of the non-canonical Wnt signaling pathway, functioning downstream of WNT5A, MAP3K7/TAK1, and HIPK2. Activation of this pathway leads to phosphorylation of SETDB1, forming the NLK-SETDB1 complex that interacts with PPARG, resulting in histone methylation and transcriptional silencing of PPARG target genes. This process inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs).
NLK also acts as a negative regulator of the canonical Wnt/β-catenin signaling pathway by phosphorylating TCF7L2/TCF4 and LEF1, disrupting their complex with β-catenin and promoting LEF1 degradation. Additionally, NLK negatively regulates the Notch signaling pathway by phosphorylating NOTCH1, preventing the formation of the active transcriptional complex with RBPJ/RBPSUH and MAML1. It also negatively regulates the MYB family of transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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