Thermo Fisher Scientific beta Tubulin Polyclonal Antibody
다양한 종에서 반응하는 베타 튜뷸린 폴리클로날 항체로 Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 신경세포 및 세포골격 연구에 활용 가능. 장기 보관 시 -20°C에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Hamster, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human beta Tubulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.44 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2792280 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Xenopus laevis (99%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
- Positive Control: 293T, A431, HeLa, HepG2, A549, H1299, HCT116, NIH-3T3, MCF7, Huh7.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene are associated with congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin has also been detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
Glutamate residues at the C-terminus of beta III tubulin can be glutamylated, though the precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, which inhibits its incorporation into microtubules.
Microtubules, composed of alpha and beta tubulin dimers (~55 kDa each), are essential cytoskeletal elements involved in chromosome segregation, intracellular transport, ciliary and flagellar movement, and structural support. Because beta-tubulin is ubiquitously expressed in eukaryotic cells, it is frequently used as a loading control in protein detection assays such as Western blotting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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