Thermo Fisher Scientific CCR5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: --

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (87%), Rat (87%), Dog (85%), Cat (83%), Pig (87%), Rabbit (82%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (86%).
• Positive Control: U87-MG, SK-N-SH, IMR32, Jurkat, Raji, NCI-H929.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1, and V28 were recently identified as HIV coreceptors.

Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, enabling fusion and entry into human white blood cells. CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 HIV complex, leading to membrane fusion and virus entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.