Thermo Fisher Scientific RUNX2 Monoclonal Antibody (1D2)
RUNX2 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, ELISA에 사용 가능. 골형성 및 골세포 분화 연구에 적합하며, 고순도 친화 크로마토그래피 정제. PBS 완충액에 보존제로 없이 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 3 µg/mL |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 10 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D2 |
| Immunogen | RUNX2 (NP_004339, 251–350 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS IHSTTPLSST RGTGLPAITD VPRRISDDDT ATSDFCLWPS TLSKKSQAGA
Target Information
RUNX2 is a nuclear protein and a member of the RUNX family of transcription factors containing a Runt DNA-binding domain. It is essential for both membranous and endochondral bone formation. RUNX2 regulates osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein binds DNA as a monomer or as part of a heterodimeric complex with higher affinity. It also enhances TGFBR1 expression in osteoblasts and cooperates with DLX5 or related factors to activate osteoblast-specific genes. Mutations in RUNX2 are associated with cleidocranial dysplasia (CCD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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