Thermo Fisher Scientific ADAMTS4 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Not determined
• Publication: Available (1)

Immunocytochemistry (ICC/IF)

• Tested Dilution: Not determined
• Publication: Available (1)

Product Specifications

Product Specific Information

PA1-33177 detects ADAMTS4 from human samples.

Target Information

This gene encodes a member of the ADAMTS protein family. Members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif.
Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major proteoglycan of cartilage) and brevican (a brain-specific extracellular matrix protein).
This cleavage suggests key roles of ADAMTS4 in arthritic disease and in the central nervous system, potentially in the progression of glioma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.