Thermo Fisher Scientific TWIST1 Polyclonal Antibody, APC
인간 TWIST1 단백질을 인식하는 Sheep 유래 Polyclonal 항체로 APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, 높은 특이성과 낮은 교차 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C 암소 보관이 권장됩니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human Twist-1 (Met1–His202) |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607736 |
Product Specific Information
In direct ELISAs, less than 16% cross-reactivity with recombinant human Twist-2 is observed.
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.
TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B, and regulates cranial suture patterning and fusion.
Mutations in the TWIST1 gene are implicated in Saethre-Chotzen syndrome, characterized by coronal synostosis, brachycephaly, facial asymmetry, hypertelorism, and broad halluces.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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