Thermo Fisher Scientific Cofilin Monoclonal Antibody (GT567)
Cofilin 단백질을 인식하는 Mouse monoclonal antibody (Clone GT567). Western blot, IHC, ICC/IF에 적합하며 Human, Mouse, Rat에 반응. 단백질 G 정제, PBS 용액 형태, 1 mg/mL 농도. 세포골격 조절 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT567 |
| Immunogen | Recombinant fragment corresponding to amino acids 1–166 of Cofilin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538741 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, A375, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat-2
- Predicted reactivity: Mouse (98%), Rat (99%), Pig (99%), Sheep (99%), Rhesus Monkey (99%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics and is important for normal mitosis and cytokinesis. Cofilin plays a critical role in cell morphology, cytoskeletal organization, and neural development, including neural tube morphogenesis and neural crest cell migration. It also facilitates the up-regulation of atypical chemokine receptor ACKR2, enhancing chemokine uptake and degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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