Thermo Fisher Scientific Phospho-BAP1 (Ser369) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of BAP1 only when phosphorylated at Ser369.

Target Information

BRCA1-associated protein-1 (BAP1) interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), which are thiol proteases catalyzing proteolytic processing of ubiquitin.
BAP1 contains an acidic region, a highly charged C-terminal region, and two putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and share overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth.
Expression studies indicate that BAP1 is expressed as a 4-kb mRNA in all tested human tissues, with a 4.8-kb transcript expressed exclusively in testis. BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene is mapped to chromosome 3p21.3, a region frequently deleted in breast and lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines, suggesting that BAP1 functions as a tumor suppressor gene in the BRCA1 growth control pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.