Thermo Fisher Scientific SUMO1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is HL60 cell lysate.
• PA5-20300 can be used with blocking peptide PEP-0424.

Target Information

SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1–SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1–4, RANBP2, or CBX4.
This post-translational modification on lysine residues of proteins plays a crucial role in cellular processes such as nuclear transport, DNA replication and repair, mitosis, and signal transduction.
SUMO1 is involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination, signaling proteasomal degradation of modified proteins. SUMO1 may regulate genes involved in palate development, and mutations can result in non-syndromic orofacial cleft 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.