Thermo Fisher Scientific ASGR1 Monoclonal Antibody (1E12)
인간 ASGR1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 ELISA에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, PBS 용액 형태로 제공됩니다. 연구용으로만 사용 가능하며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E12 |
| Immunogen | A synthetic peptide corresponding to human ASGR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GRKMKSLESQ LEKQQKDLSE DHSSLLLHVK QFVSDLRSLS CQMAALQGNG C
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates the binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on the surface of hepatocytes in a polar manner — present on sinusoidal and lateral plasma membranes but not on the bile canalicular membrane.
The mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
In rats, ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3.
The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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