Thermo Fisher Scientific ASGR1 Monoclonal Antibody (1E12)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
GRKMKSLESQ LEKQQKDLSE DHSSLLLHVK QFVSDLRSLS CQMAALQGNG C

Target Information

The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates the binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on the surface of hepatocytes in a polar manner — present on sinusoidal and lateral plasma membranes but not on the bile canalicular membrane.
The mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
In rats, ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3.
The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR and is cross-reactive with human ASGPR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.