Thermo Fisher Scientific CD163 Monoclonal Antibody (eBioGHI/61 (GHI/61)), Biotin, eBioscience
인간 CD163 단백질을 인식하는 Biotin 결합 단클론 항체. 조직 대식세포 및 단핵세포 표지에 사용. Flow Cytometry 및 IHC에 적합. IL-6, IL-10 관련 신호전달 연구에 활용 가능. 4°C 보관, 동결 금지.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- View 2 publications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/test
- View 23 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioGHI/61 (GHI/61) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_657638 |
| Filtration | 0.2 µm post-manufacturing filtered |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- Brilliant Violet 421
- Brilliant Violet 711
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and possibly hematopoietic progenitor cells. It functions as a high-affinity scavenger receptor for the hemoglobin-haptoglobin complex, aiding in hemoglobin clearance from the blood.
Upon ligand binding, CD163 initiates signal transduction leading to IL-6 and IL-10 production. IL-6 and IL-10 can induce CD163 expression, while proinflammatory stimuli such as LPS or TNF-α cause shedding of soluble CD163.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on normal human peripheral blood cells at ≤1 µg/test (100 µL final volume). Optimal titration recommended.
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein and receptor for the hemoglobin-haptoglobin complex. It protects tissues from hemoglobin-mediated oxidative damage and may contribute to iron recycling via endocytosis and heme breakdown.
CD163 is expressed on monocytes and macrophages, particularly in late inflammation phases. It is upregulated by IL-10, IL-6, and dexamethasone, and shed by LPS or PMA stimulation. CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, showing higher affinity for multimeric haptoglobin (HP1F) complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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