Thermo Fisher Scientific BARD1 Polyclonal Antibody
인간, 마우스, 랫트에서 반응하는 BARD1 단백질에 대한 Rabbit Polyclonal 항체. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. PBS buffer(50% glycerol, 0.02% sodium azide) 보존, 4°C 단기/−20°C 장기 보관.
- 카탈로그번호
- PA575304
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BARD1 Polyclonal Antibody
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human BARD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719032 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The BARD1 gene encodes a protein that interacts with the N-terminal region of BRCA1. This interaction involves conserved regions including the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in proteins regulating cell growth, such as tumor suppressors and proto-oncogenes. BARD1 also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction can be disrupted by tumorigenic mutations in BRCA1, suggesting that their stable complex formation is essential for BRCA1 tumor suppression. BARD1 may be a target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.