Thermo Fisher Scientific Phospho-RelB (Ser573) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Suggested Positive Control: HUVEC cells

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100
• Suggested Positive Control: Human breast carcinoma

Product Specifications

Target Information

The NFkB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNA-binding subunit is functionally related to c-Rel p75 and RelB p68. The p50 subunit was initially believed to be a unique protein derived from the amino-terminus of a precursor designated p105. A second protein, designated p52 (previously referred to as p49), can act as an alternative NFkB subunit. RelB does not bind with high affinity to NFkB sites, but heterodimers between RelB and p50 bind with comparable affinity to p50 NFkB homodimers. However, RelB/p50 heterodimers, unlike NFkB heterodimers, transactivate transcription of promoters containing kB binding sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.