Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 Immunohistochemistry에 적합. 인간, 마우스, 랫트 반응성. 합성 펩타이드 항원 기반으로 제작되었으며, 동결건조 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the C-terminal of mouse DRAM (Damage-regulated autophagy modulator) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: DRAM
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, promoting a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers suggests a key role in autophagy and cancer progression. At least two isoforms of DRAM are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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