Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (SM3)
인간 MUC1의 저당화 형태를 인식하는 재조합 마우스 단클론 항체. IHC, Flow Cytometry, ELISA 등 다양한 분석에 적합. HEK293 발현 시스템 기반, Protein A 정제, 액상 형태로 제공. 암 관련 MUC1 연구용으로 최적화된 항체.
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Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (SM3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SM3 |
| Immunogen | Hydrogen fluoride deglycosylated milk mucin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises the under-glycosylated form of human MUC1, a marker of tumours.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic lineages. It is a transmembrane glycoprotein with a large extracellular domain that matures through proteolysis and sequential glycosylation. MUC1 is highly polymorphic, with each allele encoding a product containing 30–90 repeats, resulting in variable molecular weights. It is abundantly expressed in over 90% of breast carcinomas and metastases. Transgenic MUC1 associates with all four cebB receptors and localizes with erbB1 (EGFR) in lactating glands. The MUC1 gene has seven exons and multiple alternatively spliced variants, some of which are fully characterized. Overexpression and aberrant glycosylation of MUC1 are linked to carcinomas.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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