Thermo Fisher Scientific Human HRK Synthetic Peptide
Human Hrk 단백질의 중심부 15개 아미노산 서열에 해당하는 합성 펩타이드로, PA5-20235 항체의 블로킹 펩타이드로 사용 가능. 인간 반응성, 액상 형태, 200 µg/mL 농도. 연구용으로만 사용하며, -20°C에서 보관.
- 카탈로그번호
- PEP0369
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human Hrk.
PEP-0369 can be used as a blocking peptide with polyclonal antibody PA5-20235.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.
Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as a novel protein induced during programmed neuronal death.
It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region similar to the BH3 motif of Bik.
Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain.
It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS.
Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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