Thermo Fisher Scientific Human HRK Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the center of human Hrk.
PEP-0369 can be used as a blocking peptide with polyclonal antibody PA5-20235.

Target Information

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.
Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as a novel protein induced during programmed neuronal death.
It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region similar to the BH3 motif of Bik.
Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain.
It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS.
Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.