Thermo Fisher Scientific CCL5 (RANTES) Polyclonal Antibody, Biotin, PeproTech
인간 CCL5(RANTES)에 특이적인 Biotin 결합 폴리클로날 항체로, ELISA 및 Western blot에 최적화됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 감도를 제공. 연구용으로 HIV 억제 관련 면역반응 연구에 활용 가능.
- 카탈로그번호
- 500-P36BT-xxxx (2개 옵션)
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CCL5 (RANTES) Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL |
| ELISA | 0.25–1.0 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived, 7.8 kDa Recombinant Human RANTES |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 0.1–1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
| RRID | AB_2930489 |
Product Specific Information
AA Sequence of recombinant protein:
SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
Preparation:
Produced from sera of rabbits immunized with highly pure Recombinant Human RANTES (CCL5). Anti-Human RANTES (CCL5)-specific antibody was purified by affinity chromatography and then biotinylated.
Sandwich ELISA:
To detect hRANTES by sandwich ELISA (using 100 µL/well antibody solution), a concentration of 0.25–1.0 µg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human RANTES (500-P36) as a capture antibody, allows the detection of at least 0.2–0.4 ng/well of Recombinant hRANTES.
Western Blot:
To detect hRANTES by Western Blot analysis, this antibody can be used at a concentration of 0.1–0.2 µg/mL. Used with compatible secondary reagents, the detection limit for Recombinant hRANTES is 1.5–3.0 ng/lane, under either reducing or non-reducing conditions.
Packaging:
500-P36BT-1MG will be provided as 2 × 500 µg.
Target Information
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It induces histamine release from basophils and activates eosinophils.
This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells and acts as a natural ligand for CCR5, suppressing replication of R5 strains of HIV-1.
Alternative splicing results in multiple transcript variants encoding different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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