Thermo Fisher Scientific CRYGS Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
GTWAVYERPN FAGYMYILPQ GEYPEYQRWM GLNDRLSSCR AVHLPSGGQY KIQIFEKGDF SGQMYETTED CPSIMEQFHM REIHSCKVLE GVWIFYELP

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 92%

Target Information

Crystallins are divided into two main classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class forms the major proteins of the vertebrate eye lens, maintaining transparency and refractive index. Lens fiber cells lose nuclei during development, so crystallins are produced once and retained for life, ensuring high stability.

Mammalian crystallins are categorized into alpha, beta, and gamma families. Beta and gamma crystallins form a superfamily, with alpha and beta further divided into acidic and basic groups. Crystallins share seven structural regions: four homologous motifs, a connecting peptide, and N- and C-terminal extensions.

Gamma-crystallins are symmetric, monomeric proteins lacking connecting peptides and terminal extensions, and are differentially regulated after early development. The CRYGS gene encodes a monomeric protein with high similarity to other gamma-crystallins and is the predominant gamma-crystallin in adult eye lens tissue. Mutations or aging-related changes in gamma-crystallins are associated with cataract formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.