Thermo Fisher Scientific CRYGS Polyclonal Antibody
Human 및 Rat 시료에 반응하는 Rabbit Polyclonal CRYGS 항체. Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRYGS. Recombinant protein control fragment (Product #RP-96492). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640182 |
Product Specific Information
Immunogen sequence:
GTWAVYERPN FAGYMYILPQ GEYPEYQRWM GLNDRLSSCR AVHLPSGGQY KIQIFEKGDF SGQMYETTED CPSIMEQFHM REIHSCKVLE GVWIFYELP
Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 92%
Target Information
Crystallins are divided into two main classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class forms the major proteins of the vertebrate eye lens, maintaining transparency and refractive index. Lens fiber cells lose nuclei during development, so crystallins are produced once and retained for life, ensuring high stability.
Mammalian crystallins are categorized into alpha, beta, and gamma families. Beta and gamma crystallins form a superfamily, with alpha and beta further divided into acidic and basic groups. Crystallins share seven structural regions: four homologous motifs, a connecting peptide, and N- and C-terminal extensions.
Gamma-crystallins are symmetric, monomeric proteins lacking connecting peptides and terminal extensions, and are differentially regulated after early development. The CRYGS gene encodes a monomeric protein with high similarity to other gamma-crystallins and is the predominant gamma-crystallin in adult eye lens tissue. Mutations or aging-related changes in gamma-crystallins are associated with cataract formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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