Thermo Fisher Scientific KIAA0556 Polyclonal Antibody
Human KIAA0556 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. Joubert 증후군 관련 연구 등 섬모 단백질 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KIAA0556. Recombinant protein control fragment: Product #RP-94967 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643010 |
Product Specific Information
Immunogen sequence:
EPPVDYSDDF ELCGDVTLQA NNTSEDRPQE LRRSLELSVN LQRKQKDCSS DEYDSIEEDI LSEPEPEDPA LVGHPRHDRP PSSGDWTQKD VHGE
Highest antigen sequence identity to the following orthologs:
- Mouse: 52%
- Rat: 51%
Target Information
This gene encodes a novel, evolutionarily conserved ciliary protein.
In human hTERT-RPE1 cells, the protein is localized at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip.
It binds to microtubules in vitro and regulates their stability when overexpressed.
Mutations in this gene have been associated with Joubert syndrome, a recessive disorder characterized by mid-hindbrain and cerebellar malformation, and other ciliopathy-related symptoms.
In serum-starvation ciliogenesis assays, fibroblast cells derived from affected patients show a reduced number of ciliated cells with abnormally long cilia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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