Thermo Fisher Scientific Chk2 Monoclonal Antibody (ABM173)
Chk2 단백질을 인식하는 Mouse monoclonal antibody (Clone ABM173). Western blot 및 IHC(P)에서 사용 가능. Human 시료 반응성. Protein A로 정제된 액상 항체로, 안정화제가 포함된 PBS buffer에 보관. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM173 |
| Immunogen | Purified recombinant CHK2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HeLa cells
- Cellular location: Nuclear
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are associated with cancer susceptibility. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins. It can also phosphorylate BRCA1, aiding in cell survival after DNA damage. CHK2 acts as a putative tumor suppressor, with mutations linked to Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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