Thermo Fisher Scientific DC-SIGN Monoclonal Antibody (5D7)
인간 DC-SIGN 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot과 IHC에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. PBS 버퍼에 0.02% sodium azide 포함. 인간 자궁 조직 라이세이트를 양성 대조로 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5D7 |
| Immunogen | A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154793 |
Product Specific Information
A suggested positive control is human uterus tissue lysate.
Target Information
This gene encodes a transmembrane receptor known as DC-SIGN, expressed on dendritic cells and macrophages. It plays a key role in the innate immune system by recognizing diverse pathogens, including parasites and viruses. The protein consists of three domains: an N-terminal transmembrane domain, a tandem-repeat neck domain, and a C-type lectin carbohydrate recognition domain. The extracellular region functions both as a pathogen recognition receptor and a cell adhesion receptor. The neck domain enables homo-oligomerization, enhancing multivalent ligand binding. Variations in the neck domain affect ligand-binding capacity. DC-SIGN is closely related to L-SIGN (GeneID 10332), differing in ligand-binding properties and tissue distribution. Multiple splicing variants exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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