Thermo Fisher Scientific APAF1 Monoclonal Antibody (2E10)
APAF1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포사멸 연구용으로 신뢰성 높은 결과를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25–0.5 µg/mL |
| Immunohistochemistry (IHC) | 0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E10 |
| Immunogen | A peptide corresponding to amino acids near the carboxy terminus of human Apaf1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154527 |
Product Specific Information
In Western blot applications, this antibody detects a band at approximately 130 kDa.
A suggested positive control is K562 cell lysate.
Target Information
The APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein includes multiple WD-40 domains, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, it forms an oligomeric apoptosome that activates caspase 9, triggering the caspase cascade leading to apoptosis.
Alternative splicing generates several transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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