Thermo Fisher Scientific APAF1 Monoclonal Antibody (5E11)
Apaf1 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체(5E11)로, 인간·생쥐·랫트에 반응합니다. ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 세포사멸 연구용으로 권장됩니다.
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Thermo Fisher Scientific APAF1 Monoclonal Antibody (5E11)
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.5 mg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5E11 |
| Immunogen | A peptide corresponding to amino acids near the carboxy terminus of human Apaf1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153336 |
Product Specific Information
A suggested positive control is K562 cell lysate.
Target Information
The APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several WD-40 domains, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, APAF1 forms an oligomeric apoptosome that activates caspase 9, triggering the caspase cascade leading to apoptosis.
Alternative splicing results in several transcript variants encoding different isoforms.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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