Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, ELISA에 적합합니다. Human, Mouse, Rat 시료 반응성이 있으며, PBS/glycerol buffer에 보관됩니다. 세포골격 연구 및 MYH9 관련 질환 연구에 유용합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MYH9 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1801–1960 of human MYH9 (NP_002464.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.79 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914078 |
Product Specific Information
- Positive test controls: HeLa, HT-29, A-549, NIH/3T3, C6
- Subcellular localization: Cytoplasm, cell cortex, cytoskeleton
Immunogen sequence:
VKSKYKASIT ALEAKIAQLE EQLDNETKER QAACKQVRRT EKKLKDVLLQ VDDERRNAEQ
YKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL EDATETADAM NREVSSLKNK
LRRGDLPFVV PRRMARKGAG DGSDEEVDGK ADGAEAKPAE
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a vital component of the actin cytoskeleton involved in cell migration, adhesion, division, and shape maintenance.
This gene spans over 106 kb, includes 41 exons, and produces a 1,960-amino-acid protein forming a hexameric complex with two heavy chains, two regulatory light chains, and two essential light chains.
Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD) such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, often associated with macrothrombocytopenia, hearing loss, renal failure, and cataracts.
MYH9 also plays a crucial role in hematopoiesis, where its dysfunction leads to hematopoietic failure and severe cytopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.