Thermo Fisher Scientific SPAG5 Polyclonal Antibody
SPAG5 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응하며 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었고, 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 942–1193 of SPAG5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.84 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2553295 |
Product Specific Information
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
- Predicted reactivity: Rat (80%), Pig (89%), Bovine (88%).
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein expressed highly in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, being essential for proper spindle formation and regulation of mitotic spindles.
SPAG5 also plays a role in sister chromatid cohesion and separation, contributing to chromosome integrity. It forms a homodimer with a long stalk and globular head domain characterized by aster-like structures.
Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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