Thermo Fisher Scientific SPAG5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, HeLa, HepG2, NT2D1
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein expressed highly in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, essential for proper spindle formation and regulation of mitotic spindles.
SPAG5 also contributes to sister chromatid cohesion and separation, maintaining chromosome integrity. It forms homodimers with a stalk and globular head domain, creating aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.