Thermo Fisher Scientific BABAM1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human BABAM1. Recombinant protein control fragment (Product #RP-103787). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BABAM1,uniProtId:Q9NWV8-1,ncbiNodeId:9606,antigenRange:106-186,antigenLength:329,antigenImageFileName:PA5-64382_BABAM1_Q9NWV8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64382_BABAM1_Q9NWV8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638451

Product Specific Information

Immunogen sequence: SLPKLESFNG SKTNALNVSQ KMIEMFVRTK HKIDKSHEFA LVVVNDDTAW LSGLTSDPRE LCSCLYDLET ASCSTFNLEG L

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.