Thermo Fisher Scientific Cyclin E Monoclonal Antibody (HE12)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-14336 targets Cyclin E in FACS, IF, IHC (P), and WB applications and shows reactivity with Human and Mouse samples.
The MA5-14336 immunogen is recombinant human cyclin E protein.

Target Information

Cyclin E belongs to the highly conserved cyclin family, characterized by a periodic fluctuation in protein abundance through the cell cycle. Cyclins act as regulators of CDK kinases, and different cyclins exhibit unique expression and degradation patterns that coordinate mitotic events.
Cyclin E forms a complex with CDK2, regulating the G1/S transition. It accumulates at the G1–S phase boundary and is degraded during S phase. Overexpression of Cyclin E has been observed in many tumors, contributing to chromosomal instability and tumorigenesis.
Cyclin E also associates with NPAT protein, which is involved in cell-cycle–regulated histone gene expression and promotes cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants encoding distinct isoforms have been identified, with two additional splice variants reported but not fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.