Thermo Fisher Scientific CADM1 Polyclonal Antibody
Thermo Fisher Scientific의 CADM1 Polyclonal Antibody는 인간 및 생쥐 시료에서 CADM1 단백질을 검출하는 고품질 항체입니다. Western blot과 ICC/IF에 사용 가능하며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장합니다.
- 카탈로그번호
- PA5106549
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CADM1 (Accession Q9BY67), corresponding to amino acid residues S105–T155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854218 |
Product Specific Information
Antibody detects endogenous levels of total CADM1.
Target Information
CADM1 mediates homophilic cell-cell adhesion in a Ca²⁺-independent manner and heterophilic adhesion with CADM3 and PVRL3. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes NK cell cytotoxicity and IFN-γ secretion by CD8⁺ cells, contributing to tumor rejection. In mast cells, CADM1 facilitates communication with nerves and is essential for mast cell development and survival with MITF. It may also function as a synaptic adhesion molecule involved in neuronal migration, axon growth, and spermatogenesis through adhesion to Sertoli cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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