Thermo Fisher Scientific Phospho-NLRP3 (Ser295) Polyclonal Antibody
인산화된 Ser295 위치의 NLRP3 단백질을 특이적으로 검출하는 폴리클로날 항체입니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 인간 및 생쥐 시료에 반응합니다. 고순도 정제 및 안정적 PBS/glycerol 보존 조건으로 연구용에 최적화되었습니다.
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Thermo Fisher Scientific Phospho-NLRP3 (Ser295) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
View 5 publications - Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NLRP3 (Accession Q96P20), corresponding to amino acid residues around phosphorylated Ser295 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816544 |
Product Specific Information
Antibody detects endogenous levels of NLRP3 only when phosphorylated at Ser295.
Target Information
The NLRP3 gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex.
This complex acts as an upstream activator of NF-kappaB signaling and plays a role in inflammation, immune response, and apoptosis. Mutations in this gene are linked to familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-105071_NLRP3_Q96P20-1_Rabbit.svg, PA5-105071_NLRP3_Q96P20-1_Rabbit_PDP.jpeg)
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