Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI2C5), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:2,000

Product Specifications

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a key target for fluoropyrimidine-based antineoplastic drugs used in solid tumor treatment.
5-FU and fluorodeoxyuridine are converted to FdUMP in tumor cells, inactivating TS through a ternary covalent complex with the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.