Thermo Fisher Scientific mature BDNF Polyclonal Antibody
mature BDNF 특이적 폴리클로날 항체로 인간, 마우스, 원숭이, 랫트 반응성. Western blot과 IHC에 적합하며, 합성 펩타이드 항원을 사용. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 신경 생존과 분화 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (IHC) | 1:500 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Guinea pig / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from c-terminal region of mature mouse BDNF conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: mature BDNF
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family.
BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Further processing generates the mature 14 kDa protein, while pro-BDNF remains biologically active and is secreted in synaptic vesicles along with the mature form.
BDNF is widely expressed in the central nervous system and acts via autocrine and paracrine mechanisms on several classes of neurons.
Signaling occurs mainly through the tyrosine kinase receptor TrkB, and also through the lower-affinity receptor p75-NTR.
BDNF promotes neuronal survival and differentiation and plays a critical role in memory formation and synaptic regulation.
Expression of BDNF is reduced in Alzheimer’s and Huntington’s disease patients and may also be involved in stress response and mood disorder biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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