Thermo Fisher Scientific IL-22 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
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Product Specifications

Product Specific Information

Antibody detects endogenous levels of total IL22.

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine and a member of the IFN–IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons). It is mainly produced by activated T cells and NK cells.
In humans, the IL-22 gene is located on chromosome 12q and structurally related to IL-10. IL-22 signals through the heterodimeric receptor complex IL-22R1/IL-10R2, activating the JAK–STAT pathway.
A soluble receptor, IL-22BP, can antagonize IL-22 binding and signaling. IL-22 primarily targets nonimmune cells such as epithelial cells of the skin, digestive and respiratory tracts, hepatocytes, and keratinocytes.
It acts as an effector cytokine of the Th17 lineage, co-expressed with IL-17A and IL-17F, and regulates genes involved in innate skin immunity. IL-22 is highly expressed during chronic inflammation, promoting wound healing, antimicrobial protein expression, and keratinocyte migration. It is critical for host defense against extracellular pathogens and mediates IL-23-induced dermal inflammation via STAT3 activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.