Thermo Fisher Scientific IL-21 Polyclonal Antibody
IL-21 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Affinity chromatography 정제, PBS/glycerol 저장, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL21 (Accession Q9HBE4), corresponding to amino acid residues K97–S147 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900043 |
Product Specific Information
Antibody detects endogenous levels of total IL21.
Target Information
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells.
In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which induces transcriptional activation by Bcl6.
IL-21 is critical for TFH cell development and effector function, and plays a role in T cell-dependent B cell differentiation into plasma and memory cells, stimulation of IgG production, and induction of apoptotic signaling in naive B cells.
In Th17 cells, IL-21 expression and feedback through STAT3, IRF4, and RORγt upregulate IL-23R, supporting maturation and maintenance by IL-23.
IL-21 also mediates downregulation of Foxp3. IL-21 deficient mice show protection from chemically-induced colitis, while elevated IL-21 levels are observed in colitis models.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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