Thermo Fisher Scientific SLC6A11 Polyclonal Antibody
SLC6A11 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin) 적용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 인간 시료 반응성 및 GABA 수송 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC6A11. Recombinant protein control fragment (Product #RP-96336) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647543 |
Product Specific Information
Immunogen sequence:
GTLPEKLQKL TTPSTDLKMR GKLGVSPRMV TVNDCDAKLK SDGTIAAITE KETHF
Ortholog sequence identity:
- Mouse: 85%
- Rat: 87%
Target Information
Slc6a11 encodes GABA transporters that are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) and mediate the rapid removal of GABA to maintain low extracellular levels.
Four 12-transmembrane domain transporters have been identified and localized to neurons and glia.
The protein encoded by the Slc6a11 gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, thereby terminating GABA neurotransmission.
Defects in the Slc6a11 gene may result in epilepsy, behavioral problems, or intellectual disabilities.
Two transcript variants encoding different isoforms have been found for the Slc6a11 gene.
Diseases associated with SLC6A11 include Tricuspid Valve Stenosis and Pulmonary Valve Insufficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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