Thermo Fisher Scientific SLC6A11 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
GTLPEKLQKL TTPSTDLKMR GKLGVSPRMV TVNDCDAKLK SDGTIAAITE KETHF

Ortholog sequence identity:

• Mouse: 85%
• Rat: 87%

Target Information

Slc6a11 encodes GABA transporters that are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) and mediate the rapid removal of GABA to maintain low extracellular levels.
Four 12-transmembrane domain transporters have been identified and localized to neurons and glia.
The protein encoded by the Slc6a11 gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, thereby terminating GABA neurotransmission.
Defects in the Slc6a11 gene may result in epilepsy, behavioral problems, or intellectual disabilities.
Two transcript variants encoding different isoforms have been found for the Slc6a11 gene.
Diseases associated with SLC6A11 include Tricuspid Valve Stenosis and Pulmonary Valve Insufficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.