Thermo Fisher Scientific PrP VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA0870)
Recombinant alpaca VHH monoclonal antibody targeting human prion protein (PrP). Compatible with direct ELISA. High purity via metal-chelate chromatography. Supplied as liquid form in PBS without preservative. For research use only.
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Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA0870 |
| Immunogen | Recombinant Human CD230/PRNP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes. Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step triggering the pathogenesis of prion neurodegenerative disorders, such as Creutzfeld-Jakob disease (CJD). PrPc is rich in alpha-helices, while PrPSc has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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