Thermo Fisher Scientific TRAIL-R2 (DR5) Humanized Recombinant Human Monoclonal Antibody (SAA2021)
Humanized recombinant monoclonal antibody targeting TRAIL-R2 (DR5), validated for ELISA and Western blot. High purity Protein A/G purified antibody expressed in CHO cells. Suitable for apoptosis and TNF-receptor signaling research. For research use only.
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Thermo Fisher Scientific TRAIL-R2 (DR5) Humanized Recombinant Human Monoclonal Antibody (SAA2021)
Applications
- Western Blot (WB): Assay-dependent
- ELISA: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / VHH-hFc |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA2021 |
| Immunogen | Recombinant Human CD262/TNFRSF10B/TRAIL-R2/DR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
Compatible with Direct ELISA.
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL that mediates TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and contains an intracellular death domain. DR5 activation by TNFSF10/TRAIL/APO-2L transduces apoptosis signals. FADD-deficient mouse studies suggest FADD is required for DR5-mediated apoptosis. Two transcript variants encoding different isoforms and one non-coding transcript have been identified. Overexpression of DR5 induces apoptosis and activates NF-κB. DR5 shows high expression in lymphocytes and spleen. Dysfunction of DR5 is associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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