Thermo Fisher Scientific Phospho-ATF2 (Thr55, Thr73) Polyclonal Antibody
ATF2 단백질의 Thr55 및 Thr73 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP에 사용 가능. 액상 형태, 1 mg/mL 농도, -20°C 보관. 세포 스트레스 신호 및 MAPK 경로 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ATF-2 around the phosphorylation site of Thr73 or Thr55 (D-L-SP-P-L) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554728 |
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Various forms of cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulate the transcriptional activity of ATF-2.
Activation occurs via phosphorylation at Thr69 and Thr71, mediated by SAPK and p38 MAPK in vitro and in transfected cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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