Thermo Fisher Scientific TRPM2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature.
Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week.
For longer storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

TRPM2 belongs to the ion transport protein family, including sodium, potassium, and calcium ion channels.
These proteins possess six transmembrane helices, with the last two flanking a loop that determines ion selectivity.
TRPM2 is activated by oxidative stress and confers susceptibility to cell death.
It functions as a calcium-permeable cation channel regulated by free intracellular ADP-ribose.
Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.