
Thermo Fisher Scientific Caspase 3 Monoclonal Antibody (5A3)
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
1:200-1:400
Immunocytochemistry (ICC/IF)
1:50-1:200
Flow Cytometry (Flow)
1:20-1:100
Product Specifications
Host/Isotype
Rabbit / IgG
Class
Monoclonal
Type
Antibody
Clone
5A3
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer`s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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