Thermo Fisher Scientific CYP3A4 Monoclonal Antibody (501CT16.1.1)
CYP3A4 단백질을 인식하는 mouse IgM 단클론 항체로, Western blot에 적합합니다. 인간 CYP3A4의 228–255번 아미노산 서열 기반 합성 펩타이드로 면역화되었습니다. 약물 대사 연구 및 CYP 효소 분석용으로 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 501CT16.1.1 |
| Immunogen | KLH conjugated synthetic peptide between 228–255 amino acids from human CYP3A4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum, and its expression is induced by glucocorticoids and some pharmacological agents.
The enzyme metabolizes approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, and erythromycin. It also metabolizes some steroids and carcinogens.
This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now considered a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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