Thermo Fisher Scientific NOTCH3 Monoclonal Antibody (487CT6.9.2)
인간 NOTCH3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 1:2,000 희석으로 사용 가능. KLH 결합 합성 펩타이드(2291–2321 aa)로 면역화됨. Protein G 정제, PBS buffer에 0.09% sodium azide 포함. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 487CT6.9.2 |
| Immunogen | KLH conjugated synthetic peptide between 2291–2321 amino acids from the C-terminal region of human NOTCH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897505 |
Target Information
NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in neural development. Homologues of the notch ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Mutations in NOTCH3 are the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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