Thermo Fisher Scientific IGF2 Monoclonal Antibody (519CT14.3.6)
IGF2 단백질을 인식하는 Mouse IgM 단일클론 항체. Western blot에 최적화되어 있으며, KLH 결합 합성 펩타이드(aa 39-68)를 면역원으로 제작됨. 액상 형태로 제공되며, 단기 4℃, 장기 -20℃ 보관 권장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 519CT14.3.6 |
| Immunogen | KLH conjugated synthetic peptide between 39–68 amino acids from human IGF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.
IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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