Thermo Fisher Scientific Mouse TSLP Receptor Synthetic Peptide
마우스 TSLP 수용체 중심부 21개 아미노산 서열로 구성된 합성 펩타이드. PA5-20380 항체의 블로킹 펩타이드로 사용 가능. PBS 완충액(pH 7.2) 내 0.1% BSA 포함, -20°C 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 21 amino acids near the center of mouse TSLP receptor.
PEP-0497 can be used as a blocking peptide with polyclonal antibody PA5-20380.
Target Information
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis, and the induction of CD4+ T cell-mediated allergic reaction.
TSLP also supports the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development.
Its receptor, TSLP-R, binds TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and formation of a functional heteromeric complex.
This heteromeric receptor requires STAT5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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