Thermo Fisher Scientific CHRM2 Monoclonal Antibody (B8E5)
CHRM2 단백질을 인식하는 Mouse monoclonal antibody (Clone B8E5). Western blot, IHC(F), ICC/IF, Functional 및 Inhibition assay에 사용 가능. Human 시료 반응성. Protein G 정제, PBS+0.1% BSA 용액 형태로 제공. 4°C 보관, Wet ice 배송.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Functional Assay (Functional) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B8E5 |
| Immunogen | Peptide VRTVEDGECYIQFFSNAAVTFGTAI(C): Human second extracellular loop residues 168–192 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091105 |
Product Specific Information
Monoclonal antibody B8E5 acts by functional dimerization of the receptor, stabilizing constitutively active receptor dimers and inducing a small decrease in carbachol affinity for the M2 receptor.
It recognizes the pentapeptide VRTVE (aa 168–172), corresponding to the N-terminal part of the second extracellular loop of the human M2 receptor.
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor that functions as a presynaptic autoreceptor inhibiting acetylcholine release.
The M2 receptor is also involved in smooth muscle contractility.
In Alzheimer’s disease, selective loss of M2 subtype receptors occurs in cortical and hippocampal regions.
Increased M2 receptor heterozygosity has been associated with depression in women.
M2 receptor expression has been reported in the brain (cerebellum, cortex, hippocampus, medulla, striatum, thalamus) as well as in lung and prostate tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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