Thermo Fisher Scientific BCL2 Monoclonal Antibody (OTI7H9), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

BCL-2 is a key regulator of apoptosis that can either inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis further.

• Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect.
• Bax and Bak play critical roles in cytochrome c release from mitochondria, initiating apoptosis.
• Constitutive expression of BCL2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
• Overexpression of BCL-2 is linked to various cancers, including B-cell lymphoma and prostate cancer.
  Two transcript variants of BCL-2 differ in their C-terminal ends due to alternative splicing.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.