Thermo Fisher Scientific ZFYVE19 Polyclonal Antibody
ZFYVE19 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 최적화. Human 시료 반응성. 항원 친화 크로마토그래피로 정제, 4°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
- Publications: [References available]
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
- Publications: [References available]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 471 of Human zinc finger, FYVE domain containing 19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
ZFYVE19 is a key regulator of the abscission step in cytokinesis and part of the cytokinesis checkpoint, which prevents premature resolution of intercellular chromosome bridges and accumulation of DNA damage.
Together with CHMP4C, it retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until checkpoint signaling is terminated at late cytokinesis.
Deactivation of AURKB leads to dephosphorylation of CHMP4C, followed by its dissociation from ZFYVE19/ANCHR and VPS4, and subsequent abscission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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